Electron Microscopy (EM) has become an extremely popular method for the ultrastructural study of macromolecules, cells, and tissues. An aqueous biological sample is frozen rapidly and irradiated with a beam of electrons. A detector senses how the electrons are scattered, and a computer reconstructs the 3D-shape of the molecule.
Why do you need this service?
- You have small amount of materials.
- The material is hard to crystallize.
- You are looking into the molecules in atomic details.
- It is a large biomolecular complex (>150 kDa, up to 2000 Å).
- You want to observe the real “native state” structure.
The Workflow of Our Cryo-EM Services (Take protein as an example)
Creative Biostructure has extensive experience in using cryo-EM technology to study dynamic conformational changes and function of macromolecular complexes and has successfully applied this technology to characterize the structures of gene therapy and drug delivery particles.
